Streptococcus constellatus is a species of Streptococcus[2] that is part of the normal flora in the oral cavity, urogenital region, and intestinal tract. However, it can frequently cause purulent infections in other parts of the body.[3] DNA homology studies and 16S rRNA sequence analysis demonstrate S. constellatus belongs to the Streptococcus anginosus group (milleri group) along with Streptococcus intermedius and Streptococcus anginosus.[4]
S. constellatus are gram positive, non-sporing, non-motile, catalase negative cocci. The cells are small, normally 0.5-1μm in diameter and form short chains. Their cell wall peptidoglycan is composed of Lys-Ala1-3 and has a DNA G+C content of 37-38%.[5]
In the presence of CO2 growth is enhanced, under aerobic conditions growth is reduced, and some strains require anaerobic conditions to grow.
S. constellatus produces major amounts of lactic acid, fermented glucose, maltose and sucrose, but not lactose and hydrolyzed aesculin.
The typical species is Lancefield Groups A,C, G, and F, with the remaining NG (non-groupable) and haemolysis on blood agar is β-haemolytic and NH (non-haemolytic).
Clinically it is associated with abscess formation in the upper body and respiratory tract. It has also been found to be involved with pulmonary exacerbations in cystic fibrosis patients and can lead to toxic shock and limb amputation.[7]
Evidence supports the further subdivision of S. constellatus into three subspecies, S. constellatus subsp. constellatus and S. constellatus subsp. pharyngis and Streptococcus constellatus subsp. viborgensis.[1]
Normally found in the oral cavities and upper respiratory tracts and isolated from purulent human infections, including appendicitis. Strains are frequently β-haemolyic and belong to Lancefield Group F or are nonhaemolytic (α and γ) and serologically ungroupable. However, a few strains react with Lancefield Group A, C, and G antisera.[8]
Most strains produce:
Most strains do NOT produce:
Normally found in infections of the human throat, patients with pharyngitis. Strains frequency are β-haemolytic and belong to Lancefield C.
Most strains produce:
Most strains do NOT produce:
Streptococcus constellatus is a species of Streptococcus that is part of the normal flora in the oral cavity, urogenital region, and intestinal tract. However, it can frequently cause purulent infections in other parts of the body. DNA homology studies and 16S rRNA sequence analysis demonstrate S. constellatus belongs to the Streptococcus anginosus group (milleri group) along with Streptococcus intermedius and Streptococcus anginosus.
